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Article

Mafb deficiency in myeloid cells increases susceptibility to Mycobacterium tuberculosis infection in mice.

Frontiers in immunology - 1 Jan 2025

Hikichi Haruka, Nakamura Hajime, Omori Shiho, Seto Shintaro, Hijikata Minako, Hamada Michito, Takahashi Satoru, Keicho Naoto

Abstract excerpt

v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is a candidate gene associated with early tuberculosis onset identified by a genome-wide association study. Here, we investigated the role of Mafb in susceptibility to Mycobacterium tuberculosis (Mtb) infection in myeloid-specific Mafb-knockout (Mafb-cKO) mice. Mtb infection was performed both in vitro using bone marrow-derived macrophages...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41660610
DOI: 10.3389/fimmu.2025.1660933
PMCID: PMC12876153

Genes

MAFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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