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Article

Oligomerization-Dependent Regulation of LrhA Controls Bacterial Flagellar Biosynthesis.

Journal of molecular biology - 1 Apr 2026

Niu Baichun, Kikkawa Masahide, Jiang Xuguang

Abstract excerpt

LysR-type transcriptional regulators (LTTRs) are a diverse family of proteins that regulate various cellular processes, including motility in bacteria. In Escherichia coli, the LTTR LrhA represses flagellar biosynthesis by inhibiting the flhDC operon. However, the structural basis underlying this regulation has remained unclear. Here, we determined both a high-resolution crystal structure and a cryo-EM...

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Identifiers

PMID: 41655832
DOI: 10.1016/j.jmb.2026.169682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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