Article
Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility.
Nucleic acids research - 1 Nov 2012
Li Bingqing, Li Ning, Wang Feng, Guo Liming, Huang Yan, Liu Xiuhua, Wei Tiandi, Zhu Deyu, Liu Cuilan, Pan Hongfang, Xu Sujuan, Wang Hong-Wei, Gu Lichuan
Abstract excerpt
YdiV is a negative regulator of cell motility. It interacts with FlhD(4)C(2) complex, a product of flagellar master operon, which works as the transcription activator of all other flagellar operons. Here, we report the crystal structures of YdiV and YdiV(2)-FlhD(2) complex at 1.9 Å and 2.9 Å resolutions, respectively. Interestingly, YdiV formed multiple types of complexes with FlhD(4)C(2). YdiV(1)-FlhD(4)C(2) and...
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