Article

Lysinoalanine crosslinking in the extracellular flagellar hook of Synergistota

2026-05-22

Abstract excerpt

Bacterial motility is driven by the flagellar motor, a conserved macromolecular complex that enables cells to navigate chemical gradients. In spirochetes, motility depends on periplasmic flagella whose function is supported by a unique post-translational modification (PTM) in the hook protein FlgE: a covalent lysinoalanine (Lal) crosslink between adjacent subunits. This modification has been shown to be conserved...

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Literature Corpus work: 4ee7c602-f50f-54e9-bedd-287f58d7954e
DOI: 10.64898/2026.05.22.727228

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