Article
The DnaK chaperone machinery converts the native FlhD2C2 hetero-tetramer into a functional transcriptional regulator of flagellar regulon expression in Salmonella.
Molecular microbiology - 1 Feb 2006
Takaya Akiko, Matsui Mari, Tomoyasu Toshifumi, Kaya Michihiro, Yamamoto Tomoko
Abstract excerpt
The DnaK chaperone binds non-specifically to many unfolded polypeptides and also binds selectively to specific substrates. Although its involvement in targeting the unfolded polypeptides to assist proper folding is well documented, less is known about its role in targeting the folded polypeptides. We demonstrate that DnaK regulates the expression of the Salmonella flagellar regulon by modulating the FlhD and FlhC...
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