Article
Genetic risk factors modulate the association between physical activity and colorectal cancer.
BMC medicine - 5 Feb 2026
Peoples Anita R, Obón-Santacana Mireia, Kim Andre E, Kawaguchi Eric S, Fu Yubo, Qu Conghui, Moratalla-Navarro Ferran, Morrison John, Lin Yi, Arndt Volker, Berndt Sonja I, Bien Stephanie A, Bishop D Timothy, Bouras Emmanouil, Brenner Hermann, Buchanan Daniel D, Campbell Peter T, Chan Andrew T, Chang-Claude Jenny, Conti David V, Corley Douglas Ac, Devall Matthew A, Dimou Niki, Drew David A, Gruber Stephen B, Gunter Marc J, Harlid Sophia, Harrison Tabitha A, Hoffmeister Michael, Hsu Li, Huyghe Jeroen R, Keku Temitope O, Kundaje Anshul, Lewinger Juan Pablo, Li Li, Lynch Brigid M, Le Marchand Loic, Martín Vicente, Murphy Neil, Newton Christina C, Ogino Shuji, Hardikar Sheetal, Ose Jennifer, Pai Rish K, Palmer Julie R, Papadimitriou Nikos, Pardamean Bens, Pellatt Andrew J, Pinchev Mila, Platz Elizabeth A, Potter John D, Rennert Gad, Ruiz-Narvaez Edward A, Sakoda Lori C, Schoen Robert E, Shcherbina Anna, Stern Mariana C, Su Yu-Ru, Thomas Claire E, Tian Yu, Tsilidis Konstantinos K, Um Caroline Y, van Duijnhoven Franzel J B, Van Guelpen Bethany, Visvanathan Kala, Wang Jun, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Ulrich Cornelia M, Peters Ulrike, Gauderman W James, Moreno Victor
Abstract excerpt
BACKGROUND: Physical activity is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene-physical activity interaction analysis. METHODS: Using logistic regression (1-d.f), two-step screening and testing method (EDGE), and joint tests (3-d.f), we analyzed interactions between common...
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