Article
Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.
Annals of surgical oncology - 1 Mar 2016
Hanyuda Akiko, Kim Sun A, Martinez-Fernandez Alejandro, Qian Zhi Rong, Yamauchi Mai, Nishihara Reiko, Morikawa Teppei, Liao Xiaoyun, Inamura Kentaro, Mima Kosuke, Cao Yin, Zhang Xuehong, Wu Kana, Chan Andrew T, Giovannucci Edward L, Meyerhardt Jeffrey A, Fuchs Charles S, Shivdasani Ramesh A, Ogino Shuji
Abstract excerpt
BACKGROUND: High-level physical activity is associated with lower colorectal cancer (CRC) mortality, likely through insulin sensitization. Insulin receptor substrate 1 (IRS1) is a mediator of insulin and insulin-like growth factor (IGF) signaling pathways, and its down-regulation is associated with insulin resistance. Therefore, we hypothesized that tumor IRS1 expression status might modify cellular sensitivity...
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