Article
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.
Nature communications - 30 Jan 2020
Papadimitriou Nikos, Dimou Niki, Tsilidis Konstantinos K, Banbury Barbara, Martin Richard M, Lewis Sarah J, Kazmi Nabila, Robinson Timothy M, Albanes Demetrius, Aleksandrova Krasimira, Berndt Sonja I, Timothy Bishop D, Brenner Hermann, Buchanan Daniel D, Bueno-de-Mesquita Bas, Campbell Peter T, Castellví-Bel Sergi, Chan Andrew T, Chang-Claude Jenny, Ellingjord-Dale Merete, Figueiredo Jane C, Gallinger Steven J, Giles Graham G, Giovannucci Edward, Gruber Stephen B, Gsur Andrea, Hampe Jochen, Hampel Heather, Harlid Sophia, Harrison Tabitha A, Hoffmeister Michael, Hopper John L, Hsu Li, María Huerta José, Huyghe Jeroen R, Jenkins Mark A, Keku Temitope O, Kühn Tilman, La Vecchia Carlo, Le Marchand Loic, Li Christopher I, Li Li, Lindblom Annika, Lindor Noralane M, Lynch Brigid, Markowitz Sanford D, Masala Giovanna, May Anne M, Milne Roger, Monninkhof Evelyn, Moreno Lorena, Moreno Victor, Newcomb Polly A, Offit Kenneth, Perduca Vittorio, Pharoah Paul D P, Platz Elizabeth A, Potter John D, Rennert Gad, Riboli Elio, Sánchez Maria-Jose, Schmit Stephanie L, Schoen Robert E, Severi Gianluca, Sieri Sabina, Slattery Martha L, Song Mingyang, Tangen Catherine M, Thibodeau Stephen N, Travis Ruth C, Trichopoulou Antonia, Ulrich Cornelia M, van Duijnhoven Franzel J B, Van Guelpen Bethany, Vodicka Pavel, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Peters Ulrike, Gunter Marc J, Murphy Neil
Abstract excerpt
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast...
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