Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13

5 Jan 2025

Abstract excerpt

• Virtual screening identifies JCS-2022 as a potential inhibitor for F13. • JCS-2022 inhibits EEV production of vaccinia virus. • JCS-2022 reduces plague size of vaccinia virus. • JCS-2022 reduces actin tail during vaccinia virus infection. The mpox virus (MPXV) treatment is crucial for public health. However, research into drugs for MPXV has fallen behind, particularly in anticipation of sudden outbreaks. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Plant Virus Research Studies
Share to Poxvirus research and outbreaks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41635305
DOI: 10.1016/j.bsheal.2024.12.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13PMID 41635305Read ↗

<i>In silico</i> repurposed drugs against monkeypox virusSemantic proximity Read ↗

The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studiesSemantic proximity Read ↗

Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses.Semantic proximity Read ↗

Structural insights into tecovirimat antiviral activity and poxvirus resistance.Semantic proximity Read ↗

Structure-Guided Repurposing of SARS-CoV-2 Compounds Identifies Putative Inhibitors of Mpox Viral EnzymesSemantic proximity Read ↗

Mechanisms of Tecovirimat Antiviral Activity and Poxvirus ResistanceSemantic proximity Read ↗

Targeting the PEDV 3CL protease for identification of small molecule inhibitors: an insight from virtual screening, ADMET prediction, molecular dynamics, free energy landscape, and binding energy calculationsSemantic proximity Read ↗

Comparative genomics and integrated system biology approach unveiled undirected phylogeny patterns, mutational hotspots, functional patterns, and molecule repurposing for monkeypox virus.Semantic proximity Read ↗

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics ApproachesSemantic proximity Read ↗

Computer-aided drug design and pharmacophore modeling towards the discovery of novel anti-Ebola agentsSemantic proximity Read ↗

Antivirals against monkeypox infectionsSemantic proximity Read ↗

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.