Article

Mechanisms of Tecovirimat Antiviral Activity and Poxvirus Resistance

2024-09-23

Abstract excerpt

<title>Abstract</title> <p>Mpox is a zoonotic disease endemic in central and west Africa. However, since 2022, human-adapted mpox virus (MPXV) strains are causing large outbreaks spreading outside these regions, leading the World Health Organization to declare public health emergency twice. Tecovirimat, the most widely used drug to treat these infections, blocks viral egress through a poorly understood mechanism....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d14b995d-b17f-58b2-9492-b420c5790d4b
DOI: 10.21203/rs.3.rs-5002222/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of Tecovirimat Antiviral Activity and Poxvirus ResistanceDOI 10.21203/rs.3.rs-5002222/v1Read

Structural insights into tecovirimat antiviral activity and poxvirus resistance.Semantic proximity Read

Notes from the Field: Mpox Cluster Caused by Tecovirimat-Resistant Monkeypox Virus - Five States, October 2023-February 2024.Semantic proximity Read

Tecovirimat Resistance in Mpox Patients, United States, 2022–2023Semantic proximity Read

Resistance to anti-orthopoxviral drug tecovirimat (TPOXX<sup>®</sup>) during the 2022 mpox outbreak in the USSemantic proximity Read

Potential of Acyclovir, Allopurinol and B Vitamins for the Treatment of Mpox Viral Infection; Insight from Molecular Docking of the Mpox Virus Multi-Domain DNA PolymeraseSemantic proximity Read

Potential therapeutic targets for Mpox: the evidence to dateSemantic proximity Read

Structure of monkeypox virus poxin: implications for drug designSemantic proximity Read

Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreakSemantic proximity Read

Prolonged viral shedding in an immunocompromised Korean patient infected with hMPXV, sub-lineage B.1.3, with acquired drug resistant mutations during tecovirimat treatmentSemantic proximity Read

A Glance at the Development and Patent Literature of Tecovirimat: The First-in-Class Therapy for Emerging Monkeypox OutbreakSemantic proximity Read

Prolonged viral shedding in an immunocompromised Korean patient infected with hMPXV, sub-lineage B.1.3, with acquired drug resistant mutations during tecovirimat treatment.Semantic proximity Read

Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat ResistanceSemantic proximity Read