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Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses.

Antiviral research - 1 Jan 2025

Cordsmeier Arne, Herrmann Alexandra, Gege Christian, Kohlhof Hella, Korn Klaus, Ensser Armin

Abstract excerpt

Monkeypox virus (MPXV) has caused a large pandemic outbreak in 2022 with more than 90.000 confirmed cases and 181 deaths. Notably, signs of microevolution and host adaption have been observed. Here, we demonstrate that viral genomes from Franconia, Bavaria acquired different mutations. Three isolates obtained from diagnostic samples, submitted from suspected Mpox cases, show differences in their replication...

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PMID: 39608644
DOI: 10.1016/j.antiviral.2024.106043

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DHODH

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