Article

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics Approaches

2024-03-13

Abstract excerpt

Lumpy skin disease (LSD), caused by a virus within the Poxviridae family and Capripoxvirus genus, induces nodular skin lesions in cattle, spreading through direct contact and insect vectors, significantly affecting global cattle farming. Despite available vaccines, their effectiveness is limited by poor bioavailability and adverse effects. Our study aimed to identify potential inhibitors targeting LSD-associated D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9b4c93e-5bdf-50f6-89e3-951ac5d4b237
DOI: 10.20944/preprints202403.0717.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics ApproachesDOI 10.20944/preprints202403.0717.v1Read

The Hunt for antipox compounds against Monkeypox Virus Thymidylate Kinase and scaffolding protein leveraging Pharmacophore modeling, molecular docking, ADMET Studies, and molecular dynamics simulation studiesSemantic proximity Read

Construction of recombinant fluorescent LSDV for high-throughput screening of antiviral drugsSemantic proximity Read

<i>In silico</i> repurposed drugs against monkeypox virusSemantic proximity Read

Genomic analysis of lumpy skin disease virus asian variants and evaluation of its cellular tropismSemantic proximity Read

Molecular characterization, phylogenetic analysis and viral load quantification of Lumpy Skin Disease Virus in CattleSemantic proximity Read

Targeting the PEDV 3CL protease for identification of small molecule inhibitors: an insight from virtual screening, ADMET prediction, molecular dynamics, free energy landscape, and binding energy calculationsSemantic proximity Read

AI-assisted identification of a novel Orthopoxvirus inhibitor targeting F13Semantic proximity Read

Structural insights into tecovirimat antiviral activity and poxvirus resistance.Semantic proximity Read

Genomic characterization of Lumpy Skin Disease virus (LSDV) from 2019 outbreak in India reveals circulation of Kenyan-like LSDV strains with unique kelch-like proteinsSemantic proximity Read

Mechanisms of Tecovirimat Antiviral Activity and Poxvirus ResistanceSemantic proximity Read

Rapid Spread and Genetic Characterisation of a Recently Emerged Recombinant Lumpy Skin Disease Virus in ThailandSemantic proximity Read

Epidemiology and genetic characteristics of the lumpy skin disease virus in Yunnan province, China from 2019 to 2023Semantic proximity Read