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Article

MetALD: Genetic Factors and Clinical Outcomes.

Seminars in liver disease - 1 Sept 2025

Israelsen Mads, Trépo Eric, Krag Aleksander, Stender Stefan

Abstract excerpt

Metabolic and alcohol-related liver disease (MetALD) is a subcategory of steatotic liver disease (SLD) characterized by the coexistence of cardiometabolic risk factors and elevated alcohol intake. The global prevalence of MetALD is estimated to be 2 to 5%, but this is likely underestimated due to self-reporting biases. In real-world settings, fluctuations in alcohol intake mean that many patients with SLD may be...

Topics

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Disease Progression
Fatty Liver
Genetic Predisposition to Disease
Lipase
Liver Diseases, Alcoholic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Multifactorial Inheritance

Source

Identifiers

PMID: 40489997
DOI: 10.1055/a-2630-0952

Genes

HSD17B13
PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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