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Article

Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis.

Hepatology (Baltimore, Md.) - 1 Apr 2025

Yuan Qiaoping, Hodgkinson Colin, Liu Xiaochen, Barton Bruce, Diazgranados Nancy, Schwandt Melanie, Morgan Timothy, Bataller Ramon, Liangpunsakul Suthat, Nagy Laura E, Goldman David

Abstract excerpt

BACKGROUND AND AIMS: Alcohol-associated hepatitis (AH) is a clinically severe, acute disease that afflicts only a fraction of patients with alcohol use disorder. Genomic studies of alcohol-associated cirrhosis (AC) have identified several genes of large effect, but the genetic and environmental factors that lead to AH and AC, and their degree of genetic overlap, remain largely unknown. This study aims to identify...

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Source

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Identifiers

PMID: 39058584
DOI: 10.1097/HEP.0000000000001027
PMCID: PMC11902603

Genes

ICOSLG
TOX4
ADH1B
RAB2B
TOX

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