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Article

Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways.

Diabetologia - 1 Jul 2026

Yu Gechang, Tam Claudia H T, Shi Mai, Hughes Alice E, Huang Chuiguo, Deng Yuzhi, Weedon Michael N, Lim Cadmon K P, Wang Chi Chiu, Chan Juliana C N, Tam Wing Hung, Lowe William, Freathy Rachel M, Oram Richard A, Ma Ronald C W

Abstract excerpt

AIMS/HYPOTHESIS: We aimed to investigate whether maternal and fetal genetic predispositions to insulin deficiency and resistance affect offspring fetal growth through distinct pathways in multi-ethnic populations. METHODS: In 5065 multi-ethnic mother-infant pairs, we examined the conditional associations of maternal and fetal partitioned polygenic risk scores (pPRSs) for type 2 diabetes-related pathways with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41634175
DOI: 10.1007/s00125-026-06669-7
PMCID: PMC13236813

Genes

ADCY5
CDKAL1
MACF1
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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