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Article

The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease.

Lancet (London, England) - 22 May 1999

Hattersley A T, Tooke J E

Abstract excerpt

Low birthweight is associated with insulin resistance, hypertension, coronary-artery disease, and non-insulin-dependent diabetes (NIDDM). A suggested explanation for this association is intrauterine programming in response to maternal malnutrition. We propose, however, that genetically determined insulin resistance results in impaired insulin-mediated growth in the fetus as well as insulin resistance in adult...

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Identifiers

PMID: 10348008
DOI: 10.1016/S0140-6736(98)07546-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease.PMID 10348008Read ↗

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