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Article

GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus.

Genome medicine - 22 May 2026

Zhou Siquan, Ran Zhichang, Li Yanliu, He Jiayuan, Yuan Xin, Hu Yuanqi, Wang Xiaoyu, Li Ruirui, Xu Yujie, Yan Ciling, Xiong Jingyuan, Cheng Guo

Abstract excerpt

BACKGROUND: The etiology of gestational diabetes mellitus (GDM) is constituted by both type 2 diabetes (T2D)-dependent and T2D-independent mechanisms. However, existing studies have evaluated the impact of T2D-dependent loci only for GDM, which limits the power to assess to what extent genetic variants or biological pathways are specific to GDM. METHODS: We subtracted the genetic effects of a genome-wide...

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Share to Diabetes, Gestational
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Pregnancy

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Identifiers

PMID: 42174728
DOI: 10.1186/s13073-026-01674-2
PMCID: PMC13371021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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