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Epigenetic signatures and genetic variants associated with muscle strength in postmenopausal women: potential bone muscle cross talk via BMP1 mechanisms.

Physiological genomics - 1 Mar 2026

da Silva Rodrigues Guilherme, Noronha Natalia Yumi, Benjamim Jonas, Sobrinho Andressa Crystine da Silva, Sousa Neto Ivo Vieira de, Sae-Lee Chanachai, Chitta Pitaksin, Kawamura Takuji, Barbosa Fernando, Nonino Carla B, Watanabe Lígia Moriguchi, Bueno Carlos Roberto

Abstract excerpt

Muscle strength decline is a hallmark of aging and contributes to frailty and bone deterioration, yet the genomic and epigenomic mechanisms predicting functional strength remain unclear. We applied a multiomics approach to identify genetic and epigenetic signatures of muscle strength variability in postmenopausal women. A total of 141 women aged 50-70 yr underwent functional tests, biochemical analysis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41633322
DOI: 10.1152/physiolgenomics.00254.2025

Genes

BMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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