Article
Designing a Hypoallergenic Mutant of Cra a 2 with T-Cell Reactivity.
Journal of agricultural and food chemistry - 18 Feb 2026
Huan Fei, Gao Shuai, Gu Yi, Li Yong-Peng, Huang Xin-Yi, Liu Meng, Yang Yang, Lai Dong, Xiao An-Feng, Liu Guang-Ming
Abstract excerpt
Crossostrea angulata arginine kinase (Cra a 2) is a major allergen responsible for oyster allergy, emphasizing the need to develop its hypoallergenic mutant for oral desensitization. In this study, a mutant Cra a 2 (mCra a 2) was generated by simultaneously substituting the four key amino acids within the conformational B-cell epitopes. These site-directed mutations altered the structure and surface electrostatic...
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