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Article

Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.

PloS one - 1 Jan 2011

Glesner Jill, Wünschmann Sabina, Li Mi, Gustchina Alla, Wlodawer Alexander, Himly Martin, Chapman Martin D, Pomés Anna

Abstract excerpt

BACKGROUND: Cockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited. The conformational epitopes for two specific monoclonal antibodies (mAb) that interfere with IgE antibody binding were identified by X-ray crystallography on opposite sites of the quasi-symmetrical cockroach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21789239
DOI: 10.1371/journal.pone.0022223
PMCID: PMC3137622

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