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Article

Four amino acids play an important role in the allergenicity of hemocyanin allergen.

International journal of biological macromolecules - 1 Aug 2024

Luan Hongwei, Lu Jiada, Shi Wenzheng, Lu Ying

Abstract excerpt

To identify the key amino acids (AAs) affecting the allergenicity of hemocyanin (HC) allergens from Chinese mitten crabs, in this study, two epitopes, P1-SHFTGSKSNPEQR and P2-LSPGANTITR were employed and four potential key AAs (P1: F3 and N9 and P2: N6 and R10) were predicted. Mast cell and mouse models revealed that four mutants induced lower levels of immunoglobulin E (IgE) and Th2 type cytokines...

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Identifiers

PMID: 38972655
DOI: 10.1016/j.ijbiomac.2024.133704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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