Article
Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance.
The Journal of antimicrobial chemotherapy - 3 Apr 2026
Gómez Londoño Luisa Fernanda, Souza Ana Camila Oliveira, Burt Brooks, Das Sourav, Ge Wenbo, Meza-Perez Vanessa, Wiederhold Nathan P, Shelat Anang A, Cuomo Christina A, Fortwendel Jarrod R, Rogers P David
Abstract excerpt
OBJECTIVES: To determine the frequency of cyp51A variants among a contemporary collection of triazole-resistant Aspergillus fumigatus clinical isolates from the USA and compare their specific contribution to reduced triazole susceptibility. METHODS: The genomes of 87 isolates with decreased susceptibility to at least one mould-active triazole antifungal collected between 2007 and 2020 were sequenced. The cyp51A...
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