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Article

Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study.

The Lancet. Microbe - 1 Aug 2025

Song Yinggai, Buil Jochem B, Rhodes Johanna, Zoll Jan, Tehupeiory-Kooreman Marlou, Ergün Mehmet, Zhang Jianhua, Li Ruoyu, Bosch Thijs, Melchers Willem J G, Verweij Paul E

Abstract excerpt

BACKGROUND: Aspergillus fumigatus is the main cause of invasive aspergillosis and triazole antifungals are the primary treatment option. The effectiveness of triazole therapy is hampered by the emergence of resistance, mainly caused by mutations in the cyp51A gene and a tandem repeat (TR) of 34 bases (TR34/Leu98His) and 46 bases (TR46/Tyr121Phe/Thr289Ala) in the promoter region, which correspond with signature...

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PMID: 40651492
DOI: 10.1016/j.lanmic.2025.101114

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