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Article

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins.

Cardiology journal - 1 Jan 2025

Yi Chengcheng, Zheng Wenyuan, Wang Junqian, Li Wenqiang, Zhang Yiming, Zhou Dan, Lei Peng, Wang Yongxiang, Bai Ming, Zhang Zheng

Abstract excerpt

BACKGROUND: This study aimed to employ Mendelian randomization (MR) analysis to investigate the causal relationship between sodium-glucose cotransporter 2 (SGLT2) inhibition and atrial fibrillation (AF), as well as assess the potential mediating role of inflammatory proteins in this association. METHODS: A two-sample MR analysis was conducted using summary-level data from the genome-wide association study (GWAS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40771123
DOI: 10.5603/cj.100340
PMCID: PMC12782545

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