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Article

A non-canonical RNAi pathway controls virulence and genome stability in Mucorales.

PLoS genetics - 1 Jul 2020

Pérez-Arques Carlos, Navarro-Mendoza María Isabel, Murcia Laura, Navarro Eusebio, Garre Victoriano, Nicolás Francisco Esteban

Abstract excerpt

Epimutations in fungal pathogens are emerging as novel phenomena that could explain the fast-developing resistance to antifungal drugs and other stresses. These epimutations are generated by RNA interference (RNAi) mechanisms that transiently silence specific genes to overcome stressful stimuli. The early-diverging fungus Mucor circinelloides exercises a fine control over two interacting RNAi pathways to produce...

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Share to Antifungal Agents
Share to Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Fungal

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Identifiers

PMID: 32658892
DOI: 10.1371/journal.pgen.1008611
PMCID: PMC7377519

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