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Article

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.

PLoS genetics - 1 Mar 2017

Calo Silvia, Nicolás Francisco E, Lee Soo Chan, Vila Ana, Cervantes Maria, Torres-Martinez Santiago, Ruiz-Vazquez Rosa M, Cardenas Maria E, Heitman Joseph

Abstract excerpt

Mucorales are a group of basal fungi that includes the casual agents of the human emerging disease mucormycosis. Recent studies revealed that these pathogens activate an RNAi-based pathway to rapidly generate drug-resistant epimutant strains when exposed to stressful compounds such as the antifungal drug FK506. To elucidate the molecular mechanism of this epimutation pathway, we performed a genetic analysis in...

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Identifiers

PMID: 28339467
DOI: 10.1371/journal.pgen.1006686
PMCID: PMC5384783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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