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Article

Differences in drug intake levels (high versus low takers) do not necessarily imply distinct drug user types: Insights from a new cluster-based model.

PloS one - 1 Jan 2026

Castaneda Diego M, Job Martin O

Abstract excerpt

BACKGROUND: A current model categorizes drug takers into high versus low takers (HT and LT) based on their drug intake levels, with the assumption that these groups represent different phenotypes. When several drug doses are considered, the inverted u-shaped dose-response curves (IUDR) of HT are shifted upwards and rightward, relative to that of LT. However, these IUDR 'shifts' are not quantitative metrics and...

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Identifiers

PMID: 41628149
DOI: 10.1371/journal.pone.0340165
PMCID: PMC12863560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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