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Article

Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis.

International journal of molecular sciences - 24 Sept 2024

Mo Qinyou, Liu Xinyu, Gong Weiming, Wang Yunzhuang, Yuan Zhongshang, Sun Xiubin, Wang Shukang

Abstract excerpt

The pathogenesis of ocular diseases (ODs) remains unclear, although genome-wide association studies (GWAS) have identified numerous associated genetic risk loci. We integrated protein quantitative trait loci (pQTL) datasets and five large-scale GWAS summary statistics of ODs under a cutting-edge systematic analytic framework. Proteome-wide association studies (PWAS) identified plasma and brain proteins associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39408566
DOI: 10.3390/ijms251910236
PMCID: PMC11476976

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