Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function.

Aging cell - 1 Feb 2026

Cai Ji-Ru, Zhang Jian, Ning Yue-Xin, Zhang Jing, Xu Tian-Ce, Liu Mei-Chen, Wang Ke-Xin, Chen Hui-Sheng

Abstract excerpt

Aging is the primary risk factor for numerous chronic diseases, making the identification of safe and effective anti-aging strategies a critical focus in biomedical research. Heterochronic parabiosis by blood exchange shows that the exchange interaction between young and old plasma can exert anti-aging effects through exchange of bloodborne factors. However, the limited plasma source greatly affects clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Bone Marrow
Share to Mesenchymal Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Phenotype

Share to Phlebotomy

Source

Open in PubMed Open full text

Identifiers

PMID: 41622984
DOI: 10.1111/acel.70400
PMCID: PMC12862434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function.PMID 41622984Read ↗

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.Semantic proximity Read ↗

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old bloodSemantic proximity Read ↗

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?Semantic proximity Read ↗

Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolismSemantic proximity Read ↗

A Two-Tier Systems Medicine Model for Human Longevity: Restorative and Regenerative Pathways to the 120-Year Lifespan PotentialSemantic proximity Read ↗

Blood Serum Stimulates p38-Mediated Proliferation and Changes in Global Gene Expression of Adult Human Cardiac Stem CellsSemantic proximity Read ↗

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional declineSemantic proximity Read ↗

Longevity Humans Have Youthful Erythrocyte Function and Metabolic SignaturesSemantic proximity Read ↗

A population-scale Red Blood Cell proteome atlas of 13,000 donors uncovers genetically encoded aging clocks predicting hemolysis, transfusion efficacy, and donor activity a decade laterSemantic proximity Read ↗

Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailtySemantic proximity Read ↗

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative diseaseSemantic proximity Read ↗

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.