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Article

Mobilization-based transplantation of young-donor hematopoietic stem cells extends lifespan in mice.

Aging cell - 1 Mar 2020

Guderyon Michael J, Chen Cang, Bhattacharjee Anindita, Ge Guo, Fernandez Roman A, Gelfond Jonathan A L, Gorena Karla M, Cheng Catherine J, Li Yang, Nelson James F, Strong Randy J, Hornsby Peter J, Clark Robert A, Li Senlin

Abstract excerpt

Mammalian aging is associated with reduced tissue regeneration and loss of physiological integrity. With age, stem cells diminish in their ability to regenerate adult tissues, likely contributing to age-related morbidity. Thus, we replaced aged hematopoietic stem cells (HSCs) with young-donor HSCs using a novel mobilization-enabled hematopoietic stem cell transplantation (HSCT) technology as an alternative to the...

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Identifiers

PMID: 32012439
DOI: 10.1111/acel.13110
PMCID: PMC7059148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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