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Article

LAH5-mediated delivery of prime editor ribonucleoprotein complexes for genome editing.

International journal of pharmaceutics - 10 Mar 2026

Yao Bing, Öktem Mert, Yang Geng, Wang Qian, Daniels Mark A, Dokter Inge, Lefferts Juliet W, Gonçalves Manuel A F V, Doevendans Pieter A, van Mil Alain, Sluijter Joost P G, Schiffelers Raymond, Mastrobattista Enrico, Lei Zhiyong

Abstract excerpt

Prime editing (PE) is a precise gene-editing technology with potential for treating genetic disorders, but efficient delivery systems remain a challenge. Viral vectors offer high efficiency but pose safety concerns related with their immunogenicity, while non-viral methods struggle with stability and scalability. Cell-penetrating peptides (CPPs) present a promising alternative due to their low immunogenicity. In...

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PMID: 41616988
DOI: 10.1016/j.ijpharm.2026.126622

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PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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