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Article

Construction of TME and Identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma.

Cancer immunology, immunotherapy : CII - 1 Jan 2022

Liu Lulu, Zhang Ruyi, Deng Jingwen, Dai Xiaomeng, Zhu Xudong, Fu Qihan, Zhang Hangyu, Tong Zhou, Zhao Peng, Fang Weijia, Zheng Yi, Bao Xuanwen

Abstract excerpt

Liver cancer accounts for 6% of all malignancies causing death worldwide, and hepatocellular carcinoma (HCC) is the most common histological type. HCC is a heterogeneous cancer, but how the tumour microenvironment (TME) of HCC contributes to the progression of HCC remains unclear. In this study, we investigated the immune microenvironment by multiomics analysis. The tumour immune infiltration characteristics of...

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Identifiers

PMID: 34028567
DOI: 10.1007/s00262-021-02967-8
PMCID: PMC10992184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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