Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder.

doi:10.1002/phar.70098

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Association of Serotonin Transporter Gene 5HTTLPR rs25531 Polymorphism With Escitalopram Efficacy in Patients With Major Depressive Disorder.

Pharmacotherapy - 1 Feb 2026

Afridi Muhammad Faisal, Zakki Shahbaz Ahmad, Rafiullah Rafiullah, Haq Ijaz Ul

Abstract excerpt

BACKGROUND: Escitalopram is considered a cornerstone therapy for major depression, but inter-individual variations exist in its clinical efficacy. The current study aims to explore the possible association between serotonin transporter gene (SLC6A4) polymorphism 5HTTLPR-rs25531 and clinical efficacy of escitalopram in a Pakistani population suffering from major depressive disorder. METHODOLOGY: This prospective...

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PMID: 41606417
DOI: 10.1002/phar.70098

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SLC6A4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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