Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

The association of Alzheimer's disease-related SNPs with mild cognitive impairment susceptibility in the Chinese population.

Scientific reports - 28 Jan 2026

Xie Zhilan, Tu Wuzi, Ye Xiao-Fei, Hua Li, Zhang Xiaohong, Feng Nannan

Abstract excerpt

Previous Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD), whereas their associations with mild cognitive impairment (MCI) remain unclear. To evaluate the associations between 100 representative AD-associated SNPs and susceptibility to MCI in the Chinese population. We recruited 200 MCI patients and 200 cognitively-healthy...

Topics

Aged
Female
Humans
Male
Adaptor Proteins, Signal Transducing
Alzheimer Disease
Case-Control Studies
China
Clusterin
Cognitive Dysfunction
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

LDL-Receptor Related Proteins

Membrane Transport Proteins

Methylenetetrahydrofolate Reductase (NADPH2)

Mitochondrial Precursor Protein Import Complex Proteins

Monomeric Clathrin Assembly Proteins

Nitric Oxide Synthase Type III

Source

Open in PubMed Open full text

Identifiers

PMID: 41606232
DOI: 10.1038/s41598-026-37309-0
PMCID: PMC12910095

Genes

CLU
BIN1
MTHFR
NOS3
PICALM
SORL1
TOMM40
APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of Alzheimer's disease-related SNPs with mild cognitive impairment susceptibility in the Chinese population.PMID 41606232Read ↗

Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Validating GWAS-Identified Risk Loci for Alzheimer's Disease in Han Chinese Populations.Semantic proximity Read ↗

Analysis of cognitive performance and polymorphisms of SORL1, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU, and BIN1 in patients with mild cognitive impairment and cognitively healthy controls.Semantic proximity Read ↗

Evaluation of mild cognitive impairment genetic susceptibility risks in a Chinese population.Semantic proximity Read ↗

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese populationSemantic proximity Read ↗

Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment.Semantic proximity Read ↗

Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.Semantic proximity Read ↗

SORL1 genetic variants modulate risk of amnestic mild cognitive impairment in northern Han Chinese.Semantic proximity Read ↗

Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study.Semantic proximity Read ↗

Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.Semantic proximity Read ↗

Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population.Semantic proximity Read ↗

Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.