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Comprehensive risk factor analysis of sick sinus syndrome: a genetic, sociodemographic, clinical and laboratory investigation using the UK Biobank data.

Heart (British Cardiac Society) - 11 Sept 2026

Kim Hong-Ju, Yang Pil-Sung, Park Hanjin, Kim Daehoon, Bae Han-Joon, Lee Chan-Hee, Son Jang-Won, Kim Ung, Joung Boyoung

Abstract excerpt

BACKGROUND: Sinoatrial node dysfunction and atrial fibrillation (AF) often coexist, and each potentially initiates or perpetuates the other. Consequently, genetic risk factors for AF may be associated with sick sinus syndrome (SSS). This study evaluated clinical, sociodemographic, laboratory and genetic factors in predicting the SSS incidence by using a polygenic risk score (PRS) for AF, given the absence of a...

Read the complete abstract on PubMed

Topics

Humans
Male
Middle Aged
Sick Sinus Syndrome
Female
United Kingdom

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Adult

Risk Factors

Incidence

Risk Assessment

Genetic Risk Score

Atrial Fibrillation

UK Biobank

Genetic Predisposition to Disease

Biological Specimen Banks

Source

Identifiers

PMID: 41605626
DOI: 10.1136/heartjnl-2025-327272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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