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Article

From Environment to Genome and Back: A Lesson from HFE Mutations.

International journal of molecular sciences - 15 May 2020

Rametta Raffaela, Meroni Marica, Dongiovanni Paola

Abstract excerpt

The environment and the human genome are closely entangled and many genetic variations that occur in human populations are the result of adaptive selection to ancestral environmental (mainly dietary) conditions. However, the selected mutations may become maladaptive when environmental conditions change, thus becoming candidates for diseases. Hereditary hemochromatosis (HH) is a potentially lethal disease leading...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32429125
DOI: 10.3390/ijms21103505
PMCID: PMC7279025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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