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Article

Human blood cell traits and sporadic lymphangioleiomyomatosis: results from mediation joint multi-omics and eQTL Mendelian randomization analysis.

Orphanet journal of rare diseases - 27 Jan 2026

Liu Tianshu, Cai Yiting

Abstract excerpt

BACKGROUND: To investigate the genetic causality between Human blood cell (HBC) traits and sporadic lymphangioleiomyomatosis (sLAM) by mediation joint multi-omics and eQTL Mendelian randomization analysis. METHODS: Quality control processes were followed to select eligible instrumental variables strongly associated with 35 kinds of HBC traits. Independent cohort of European ancestry with sLAM and lung function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41593677
DOI: 10.1186/s13023-026-04224-6
PMCID: PMC12918586

Genes

L3MBTL3
EGFL8
PAX8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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