From paradox to biology: shared genetic architecture underlies the inverse association between smoking and Sjögren's disease.

Abstract excerpt

OBJECTIVES: Smoking has been consistently associated with a paradoxically lower risk of Sjögren's disease (SjD). We used genetic approaches to investigate whether this association reflects a causal effect of smoking or shared genetic architecture, and to identify shared loci that may help explain this paradox and inform disease biology. METHODS: We applied an integrated cross-trait genetic framework using...

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• Genetic Pleiotropy
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide