Article
Proteomic footprint of serum urate concentration and urate transporter ABCG2 dysfunctional polymorphism: a cross-sectional study.
RMD open - 27 Jan 2026
Ohashi Yuki, Ichihara Sahoko, Yamamoto Ken, Kitamura Yuki, Matsubara Tatsuaki, Beppo Ruriha, Kinoshita Fumie, Kato Tomoko S, Toyoda Yu, Kawamura Yusuke, Matsuo Hirotaka, Ichida Kimiyoshi, Yokota Mitsuhiro, Nakatochi Masahiro
Abstract excerpt
BACKGROUND: Existing proteomic studies have primarily focused on gout flares or symptomatic hyperuricaemia, and few have comprehensively investigated circulating proteomic profiles in serum urate (SU) concentration as a continuous quantitative trait. This cross-sectional study investigated the association between SU concentration and serum proteomic profiles. METHODS: We enrolled 176 Japanese individuals aged ≥50...
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