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Article

Meiotic double-strand DNA breaks and spontaneous mutation in Drosophila melanogaster.

G3 (Bethesda, Md.) - 1 Apr 2026

Melde Rob, Daigle Austin, Abraham JoHanna, Sharp Nathaniel

Abstract excerpt

The exchange of genetic material during meiosis requires the formation and repair of DNA double-strand breaks (DSBs), which may not be repaired with perfect fidelity. If meiotic exchange is mutagenic, this would add to the costs of sexual reproduction and affect patterns of genome evolution, but much of the evidence for this is indirect. In the fruit fly Drosophila melanogaster, it is possible to completely...

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Identifiers

PMID: 41589060
DOI: 10.1093/g3journal/jkag019
PMCID: PMC13042288

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