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Article

Validation of a novel genomic biomarker of mesenchymal stem cell scalability and implications of genotype status on cellular senescence phenotypes.

Scientific reports - 26 Jan 2026

Ardana I Kade Karisma Gita, Maldonado Vitali V, Barnes C Lowry, Samsonraj Rebekah M

Abstract excerpt

Ex vivo expansion impairs the regenerative potential of bone marrow-derived mesenchymal stem cells (BM-MSCs), primarily by inducing cellular senescence. Interestingly, populations of BM-MSCs that exhibit resistance to senescence even after prolonged expansion have been reported. However, a reliable strategy to identify these populations is still underway. Previously, the GSTT1 gene has been identified as a...

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Identifiers

PMID: 41588136
DOI: 10.1038/s41598-026-37517-8
PMCID: PMC12905334

Genes

GSTT1
MSC
ACTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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