Article
A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability.
Stem cells (Dayton, Ohio) - 1 Sept 2020
Sathiyanathan Padmapriya, Samsonraj Rebekah M, Tan Clarissa L L, Ling Ling, Lezhava Alexander, Nurcombe Victor, Stanton Lawrence W, Cool Simon M
Abstract excerpt
Although the application of human mesenchymal stem cells (hMSCs) to repair damaged or diseased tissues has proven relatively effective, both the donor-to-donor variability in ex vivo expansion rates and the maintenance of stemness remain a bottleneck to widespread translation. Previous work from this laboratory stratified donors into those yielding hMSCs with high- or low-growth capacity; global transcriptomic...
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