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Article

Mechanistic insights into mitochondrial tRNAAla 3'-end metabolism deficiency.

The Journal of biological chemistry - 1 Jul 2021

Ji Yanchun, Nie Zhipeng, Meng Feilong, Hu Cuifang, Chen Hui, Jin Lihao, Chen Mengquan, Zhang Minglian, Zhang Juanjuan, Liang Min, Wang Meng, Guan Min-Xin

Abstract excerpt

Mitochondrial tRNA 3'-end metabolism is critical for the formation of functional tRNAs. Deficient mitochondrial tRNA 3'-end metabolism is linked to an array of human diseases, including optic neuropathy, but their pathophysiology remains poorly understood. In this report, we investigated the molecular mechanism underlying the Leber's hereditary optic neuropathy (LHON)-associated tRNAAla 5587A>G mutation, which...

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Identifiers

PMID: 34023389
DOI: 10.1016/j.jbc.2021.100816
PMCID: PMC8212662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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