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Article

Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies

30 Dec 2020

Abstract excerpt

The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically remodels during cardiac disease. This review examines DGC remodeling as a common denominator in diseases affecting heart function and health. Dystrophin and the DGC serve as broad cytoskeletal integrators that are critical for maintaining stability of muscle membranes. The presence of pathogenic variants in genes encoding proteins...

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PMID: 33387942
DOI: 10.1016/j.advms.2020.12.004

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