Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

19 Mar 2021

Abstract excerpt

Abstract Mechanical stress induced by contractions constantly threatens the integrity of muscle Z-disc, a crucial force-bearing structure in striated muscle. The PDZ-LIM proteins have been proposed to function as adaptors in transducing mechanical signals to preserve the Z-disc structure, however the underlying mechanisms remain poorly understood. Here, we show that LDB3, a well-characterized striated muscle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Genetic Neurodegenerative Diseases
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33742095
DOI: 10.1038/s42003-021-01864-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulationPMID 33742095Read ↗

AAV-Delivered RNAi Targeting Mutant LDB3 Prevents and Reverses Myofibrillar Myopathy through Mechanosignaling RestorationSemantic proximity Read ↗

The Role of Z-disc Proteins in Myopathy and Cardiomyopathy.Semantic proximity Read ↗

Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiationSemantic proximity Read ↗

Cardiomyopathy-associated and basic residue mutations in myopalladin alter actin binding, bundling, and structural stability.Semantic proximity Read ↗

The Sarcomeric Z‐Disc and Z‐DiscopathiesSemantic proximity Read ↗

Expression of LIM domain-binding 3 (LDB3), a striated muscle Z-band alternatively spliced PDZ-motif protein in the nervous systemSemantic proximity Read ↗

Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.Semantic proximity Read ↗

Structure and Function of Filamin C in the Muscle Z-Disc.Semantic proximity Read ↗

Telethonin and other new proteins of the Z-disc of skeletal muscle.Semantic proximity Read ↗

Expression of striated muscle Z-band alternatively spliced PDZ-motif protein LIM domain-binding 3 in the nervous systemSemantic proximity Read ↗

Cardiomyopathy-Associated and Basic Residue Mutations in Myopalladin Alter Actin Binding, Bundling, and Structural StabilitySemantic proximity Read ↗

The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.