Article

The genetic architecture of fibromyalgia across 2.5 million individuals

2025-09-19

Abstract excerpt

Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk loci for fibromyalgia. The strongest association was with a coding variant in HTT , the causal gene for Huntington’s disease. Gen...

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Literature Corpus work: 70a8e289-9930-5510-9908-a3ebb1aa3670
DOI: 10.1101/2025.09.18.25335914

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