Article
The genetic architecture of fibromyalgia across 2.5 million individuals.
Nature medicine - 1 Aug 2026
Kerrebijn Isabel, Bjornsdottir Gyda, Arbabi Keon, Urpa Lea, Haapaniemi Hele, Thorleifsson Gudmar, Stefansdottir Lilja, Frangakis Stephan, Valliere Jesse, Kunorozva Lovemore, Abner Erik, Ji Caleb, Kangur Markus, Aagaard Bitten, Bliddal Henning, Brunak Søren, Bruun Mie T, Didriksen Maria, Erikstrup Christian, Finer Sarah, Geirsson Arni J, Gudbjartsson Daniel F, Hansen Thomas F, van Heel David, Jonsdottir Ingileif, Knight Stacey, Knowlton Kirk U, Mikkelsen Christina, Nadauld Lincoln D, Olafsdottir Thorunn A, Ostrowski Sisse R, Pedersen Ole B V, Saevarsdottir Saedis, Skuladottir Astros T, Sørensen Erik, Stefansson Hreinn, Sulem Patrick, Sveinsson Olafur A, Thorlacius Gudny E, Thorsteinsdottir Unnur, Ullum Henrik, Vikingsson Arnor, Werge Thomas M, Saxena Richa, Stefansson Kari, Brummett Chad M, Glintborg Bente, Clauw Daniel J, Thorgeirsson Thorgeir E, Williams Frances M K, Sinnott-Armstrong Nasa, Ollila Hanna M, Wainberg Michael
Abstract excerpt
Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying 26 risk loci for fibromyalgia. The strongest association was with a coding variant in HTT, the causal gene for Huntington's disease. Gene...
Topics
- Humans
- Fibromyalgia
- Genome-Wide Association Study
- Female
- Genetic Predisposition to Disease