Shared genetic risk between functional somatic syndromes, internalizing disorders, and immune-mediated diseases: a twin-sibling study.

doi:10.1016/j.bbi.2026.106837

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Article

Shared genetic risk between functional somatic syndromes, internalizing disorders, and immune-mediated diseases: a twin-sibling study.

Brain, behavior, and immunity - 1 Oct 2026

Steen Olivier D, Ohlsson Henrik, van Ockenburg Sonja L, Kendler Kenneth S, Rosmalen Judith G M, Sundquist Kristina, van Loo Hanna M

Abstract excerpt

Functional somatic syndromes frequently co-occur with internalizing disorders such as anxiety disorders and major depressive disorder. Both show familial associations with immune-mediated diseases. Here, we estimate genetic and environmental contributions to functional somatic syndromes and their overlap with immune-mediated diseases, with internalizing disorders included for comparison. The study sample...

Read the complete abstract on PubMed

Topics

Humans
Female
Genetic Predisposition to Disease
Fibromyalgia
Sweden
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fatigue Syndrome, Chronic

Major Depressive Disorder

Irritable Bowel Syndrome

Anxiety Disorders

Siblings

Somatoform Disorders

Adult

Risk Factors

Registries

Immune System Diseases

Twins

Gene-Environment Interaction

Source

Open in PubMed

Identifiers

PMID: 42190845
DOI: 10.1016/j.bbi.2026.106837

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