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Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1

5 Jun 2014

Abstract excerpt

Ppp2r1a encodes the scaffold subunit Aalpha of protein phosphatase 2A (PP2A), which is an important and ubiquitously expressed serine threonine phosphatase family and plays a critical role in many fundamental cellular processes. To identify the physiological role of PP2A in female germ cell meiosis, we selectively disrupted Ppp2r1a expression in oocytes by using the Cre-Loxp conditional knockout system. Here we...

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PMID: 24899574
DOI: 10.1095/biolreprod.114.120220

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