Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches.

European journal of pharmacology - 5 Nov 2024

Mafi Sahar, Dehghani Mehdi, Khalvati Bahman, Abidi Hassan, Ghorbani Marziyeh, Jalali Pooya, Whichelo Rachel, Salehi Zahra, Markowska Aleksandra, Reyes Amanda, Pecic Stevan, Łos Marek J, Ghavami Saeid, Nikseresht Mohsen

Abstract excerpt

Colorectal cancer (CRC) ranks among the leading causes of cancer-related deaths worldwide. Enhancing CRC diagnosis and prognosis requires the development of improved biomarkers and therapeutic targets. Emerging evidence suggests that the unfolded protein response (UPR) plays a pivotal role in CRC progression, presenting new opportunities for diagnosis, treatment, and prevention. This study hypothesizes that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to eIF-2 Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Chaperone BiP

Share to Endoplasmic Reticulum Stress

Share to Heat-Shock Proteins

Share to Molecular Docking Simulation

Share to Molecular Targeted Therapy

Share to Protein Interaction Maps

Source

Identifiers

PMID: 39153651
DOI: 10.1016/j.ejphar.2024.176899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches.PMID 39153651Read ↗

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targetsSemantic proximity Read ↗

Unfolded protein response in colorectal cancerSemantic proximity Read ↗

Characterization of endoplasmic reticulum stress unveils ZNF703 as a promising target for colorectal cancer immunotherapySemantic proximity Read ↗

A Novel Lipid Metabolism and Endoplasmic Reticulum Stress-Related Risk Model for Predicting Immune Infiltration and Prognosis in Colorectal CancerSemantic proximity Read ↗

Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancerSemantic proximity Read ↗

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)Semantic proximity Read ↗

Systematic Analysis of the Aberrances and Functional Implications of UPR in Hepatocellular CarcinomaSemantic proximity Read ↗

Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization studySemantic proximity Read ↗

PERK-Olating Through Cancer: A Brew of Cellular DecisionsSemantic proximity Read ↗

GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention researchSemantic proximity Read ↗

A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis.Semantic proximity Read ↗

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.